林娟 “国家高层次青年人才”，福建省“闽江学者”特聘教授，“南强青年拔尖A类人才”，博士生导师 研究方向：细胞坏死的调节机制及其在炎症性疾病中的作用 所在系部：yl23411永利官网登录抗癌中心 邮    箱：linjuan2020 @xmu.edu.cn 网页: https:/info/1236/4590.htm

研究领域

细胞死亡对机体维持自身稳态平衡有着至关重要的作用，当细胞坏死的时候，细胞膜破裂，内容物释放，可能导致大量的炎症反应，炎症反应失去控制就会导致急性或慢性的炎症性和免疫性疾病。虽然很早以前就有研究发现发炎的组织中存在坏死细胞，但直到近年来，随着对细胞坏死机制的理解加深，其促炎作用才逐渐引起注意。

实验室目前主要的研究方向如下：

（一）细胞坏死的调节机制；

（二）细胞坏死在炎症性和免疫性疾病中的作用；

学习经历

2004~2008 厦门大学生命科学学院生物科学          理学学士

2008~2013 厦门大学生命科学学院生化与分子生物学  理学博士

工作经历

2013~2020德国科隆大学遗传所/CECAD研究中心     博士后

2020.11~  yl23411永利官网登录                         教授

代表性成果

Imai T*, Lin J*#, Kaya GG, Ju E, Kondylis V, Kelepouras K, Liccardi G, Kim C, Pasparakis M#. The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation. Immunity. 2024 Jul 9;57(7):1497-1513.

*These authors contributed equally to this work.

# Corresponding authors.

Lin J*, Kumari S*, Kim C*, Van T-M*, Wachsmuth L, Polykratis A & Pasparakis.M (2016). RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature, 540: 124-128;

*These authors contributed equally to this work.

3.  Lin J*, Li H*, Yang M, Ren J, Huang Z, Han F, Huang J, Ma J, Zhang D, Zhang Z, Wu J, Huang D, Qiao M, Jin G, Wu Q, Huang Y, Du J, Han J (2013). A role of RIP3-mediated macrophage necrosis in atherosclerosis development. Cell Rep., 3(1):200-210.

*These authors contributed equally to this work.

所有论文列表

1. Imai T*, Lin J*#, Kaya GG, Ju E, Kondylis V, Kelepouras K, Liccardi G, Kim C, Pasparakis M#. The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation. Immunity. 2024 Jul 9;57(7):1497-1513.

*These authors contributed equally to this work.

# Corresponding authors.

2. Lin J*, Kumari S*, Kim C*, Van TM, Wachsmuth L, Polykratis A, Pasparakis M. RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature. 2016 Dec 1; 540(7631):124-128.

*These authors contributed equally to this work.

3. Juan Lin*, Hanjie Li*, Min Yang, Junming Ren, Zhe Huang, Felicia Han, Jian Huang, Jianhui Ma, Duanwu Zhang, Zhirong Zhang, Jianfeng Wu, Deli Huang, Muzhen Qiao, Guanghui Jin, Qiao Wu, Yinghui Huang, Jie Du and Jiahuai Han. A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development. Cell Rep. 2013 Jan 31; 3(1):200-10

*These authors contributed equally to this work.

4. Lisheng Li, Wanze Chen, Yaoji Liang, Huabin Ma, Wenjuan Li, Zhenru Zhou, Jie Li, Yan Ding, Junming Ren, Juan Lin, Felicia Han, Jianfeng Wu & Jiahuai Han.The Gβγ-Src signaling pathway regulates TNF-induced necroptosis via control of necrosome translocation. Cell Research, 2014, 24, 417–432.

5. Dannappel M*, Vlantis K*, Kumari S*, Polykratis A*, Kim C, Wachsmuth L, Eftychi C, Lin J, Corona T, Hermance N, Zelic M, Kirsch P, Basic M, Bleich A, Kelliher M, Pasparakis M. RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature. 2014 Sep 4; 513(7516):90-4.

*These authors contributed equally to this work.

6. Huipeng Jiao*, Laurens Wachsmuth*, Snehlata Kumari, Robin Schwarzer, Juan Lin, Remzi Onur Eren, Amanda Fisher, Rebecca Lane, George R Young, George Kassiotis , William J Kaiser, Manolis Pasparakis. Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation. 2020 Nature 580, 391–395.

*These authors contributed equally to this work.

7. Duanwu Zhang, Juan Lin and Jiahuai Han. Receptor-interacting protein (RIP) kinase family. Cell Mol Immunol. 2010 Jul; 7(4):243-9

6. Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science. 2009 Jul 17; 325(5938):332-6