研究领域

现主要研究用于中枢神经系统PET/SPECT 显像的小分子放射性探针的设计、合成、标记以及体内外评价等工作。

学习和工作经历

2009.09至2014.07, 北京师范大学, 化学学院, 博士(硕博连读), 导师: 刘伯里 院士

2012.12至2014.04, 纽约大学, 医学院, 公派联合培养

2005.09至2009.07, 北京师范大学, 化学学院, 学士

代表性成果

[1] Chunyan Li^#,* Wanfei Li^#, Huanhuan Liu, Yejun Zhang, Guangcun Chen, Zijing Li*, Qiangbin Wang*. Activatable NIR-II Nanoprobe for In Vivo Early Real-Time Diagnosis of Traumatic Brain Injury. Angew. Chem. Int. Ed., 2020, 59 (1), 247-252.

[2] Huawei Hong^#, Lei Zhang, Fang Xie, Rongqiang Zhuang, Donglang Jiang, Huanhuan Liu, Jindian Li, Hongzhang Yang, Xianzhong Zhang, Liming Nie*, Zijing Li*. Rapid One-Step ¹⁸F-Radiolabeling of Biomolecules in Aqueous Media by Organophosphine Fluoride Acceptors. Nat. Commun., 2019, 10(1):989.

[3] Yajing Liu^#, Huanhuan Liu^#, Huixiang Yan, Yingchao Liu, Jinsen Zhang, Wenjun Shan, Puxiang Lai, Honghui Li, Lei Ren, Zijing Li*, Liming Nie*.Aggregation-Induced Absorption Enhancement for Deep Near-Infrared II Photoacoustic Imaging of Brain Gliomas In Vivo. Adv. Sci., 2019, 1801615.

[4] Huanhuan Liu^#, Xiangyu Wang, Yanfang Huang, Honghui Li, Chenyu Peng, Hongzhang Yang, Jindian Li, Huawei Hong, Zhao Lei, Xiaofen Zhang, Zijing Li*. Biocompatible CroconaineAggregates with Strong 1.2-1.3 μm Absorption for NIR-IIa Photoacoustic Imaging in Vivo. ACS Appl. Mater. Interfaces, 2019, 11 (34): 30511-30517.

[5] Hualong Fu^#, Weiting Tang, Zhen Chen, Vasily V. Belov, Genwei Zhang, Tuo Shao, Xiaofei Zhang, Qingzhen Yu, Jian Rong, Xiaoyun Deng, Wei Han, Scott Myers, Pilar Giffenig, Lu Wang, Lee Josephson, Yihan Shao, April Davenport, James Daunais, Mikhail I Papisov, Hongjie Yuan, Zijing Li*, Stephen F. Traynelis*; Steven H Liang*. Synthesis and Preliminary Evaluations of a Triazole-cored Antagonist ([¹⁸F]N2B-0518) as PET Imaging Probe for GluN2B Subunit in the Brain. ACS Chem. Neurosci. 2019, 10, 5, 2263-2275.

[6] Hualong Fu^#, Zhen Chen, Lee Josephson, Zijing Li*, Steven H. Liang*. Positron Emission Tomography (PET) Ligand Development for Ionotropic Glutamate Receptors: Challenges and Opportunities for Radiotracer Targeting N Methyl D aspartate (NMDA), α Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA), and Kainate Receptors. J. Med. Chem., 2019, 62 (2), pp 403-419.

[7] Longguang Tang^#, Chenyu Peng^#, Bowen Tang, Zijing Li*, Xiangyu Wang, Jindian Li, Fei Gao, Lumei Huang, Duo Xu, Pu Zhang, Rongqiang Zhuang, Xinhui Su, Xiaoyuan Chen, Xianzhong Zhang*. Radioiodinated small molecule tyrosine kinase inhibitor for HER2 selective SPECT imaging. J. Nucl. Med., 2018, 59, 1386-1391.

[8] Lumei Huang^#, Zijing Li*, Deliang Zhang, Hua Li, Changrong Shi, Pu Zhang, Xinhui Su, Xianzhong Zhang*. Highly Specific and Sensitive Radioiodinated Agent for In Vivo Imaging of Superoxide through Superoxide-initiated Retention. Anal. Chem., 2018, 90 (21), 12971–12978.

[9] Yajing Liu^#, Yanping Yang, Mingjian Sun, Mengchao Cui, Ying Fu, Yu Lin, Zijing Li*, Liming Nie*. Highly specific noninvasive photoacoustic and positron emission tomography of brain plaque with functionalized croconium dye labeled by a radiotracer.Chem. Sci., 2017, 8, 2710-2716.

[10] Hua Li^#, Deliang Zhang, Mengna Gao, Lumei Huang, Longguang Tang, Zijing Li*, Xiaoyuan Chen, Xianzhong Zhang*. Highly Specific C-C Bond Cleavage Induced FRET Fluorescence for In Vivo Biological Nitric Oxide Imaging.Chem. Sci., 2017, 8, 2199-2203.

[11] Zijing Li*^#, Xuran Zhang^#, Xiaoyang Zhang, Mengchao Cui, Jie Lu, Xiaodong Pan*, Xianzhong Zhang*. ¹⁸F-Labeled Benzyldiamine Derivatives as Novel Flexible Probes for Positron Emission Tomography of Cerebral β-Amyloid Plaques.J. Med. Chem., 2016, 59(23), 10577−10585.

获得专利

（1）李子婧；洪华伟；庄荣强；刘欢欢；杨鸿章；氟代氧化膦类化合物及其在正电子发射显像中的应用,2018-5-28, 中国, ZL 2018 1 0525197.9.

（2）张现忠；李化；黄路梅；季悦；李子婧；郭志德；一种放射性标记的肿瘤显像剂、其制备方法和应用, 2019-01-15, 中国, ZL 2016 1 0307569.1.

（3）崔孟超；刘伯里；李子婧；一类与Aβ斑块具有高亲和力的小分子化合物及其合成和应用,2009-7-31,中国, ZL 2009 1 0090109.8.

主持重要课题

（1）国家自然科学基金面上项目，81971674，基于有机磷氟受体的快速一步水相18F标记方法及其应用于肿瘤PET成像研究，2020.01-2023.12，55万元，在研，主持

（2）福建省杰出青年科学基金项目，2019J06006，中枢神经系统炎症分子影像研究，2019.07-2022.6，30万元，在研，主持

（3）国家自然科学基金青年科学基金项目，81501534，基于二氢吡啶结构的一氧化氮分子探针的制备及其PET显像研究，2016.01-2018.12，18万元，结题，主持