赵 云 助理教授 学科(方向):药理学 所在系部:基础医学部 办公电话:0592-21888681 邮 箱:zy2008@xmu.edu.cn
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研究领域:
(1)中药活性成分;
(2)心血管药理。
学习经历:
1998/9 ~2002/7 华中科技大学同济医学院,药学学士;
2002/9 ~2004/7 华中科技大学同济医学院,药理学硕士;
2004/9 ~2007/7 华中科技大学同济医学院,药理学博士。
工作经历:
2007/7-至今 yl23411永利官网登录,助理教授
代表性成果:
1. Enhui Yao#, Guixiang Zhang#, Jinhua Huang, Xiazhen Yang, Lu Peng, Xuefeng Huang, Xiaoxin Luo, Jie Ren, Rui Huang, Lichao Yang, Yu Zhou, Rengong Zhuo, Yun Zhao*, Xin Jin*. Immunomodulatory effect of oleoylethanolamide in dendritic cells via TRPV1/AMPK activation. Journal of Cellular Physiology, 2019: 1-16.
2. Yun Zhao#, Lu Yan#, Lu Peng, XueFeng Huang, GuiXiang Zhang, BingqQian Chen, Jie Ren, Yu Zhou, LiChao Yang, Li Peng, Xin Jin*, YiQing Wang*. Oleoylethanolamide alleviates macrophage formation via AMPK/PPAR/STAT3 pathway. Pharmacological Reports, 2018, 70(6): 1185-1194.
3. Yun Zhao#, Yijun Liu#, Zuo Jing#, Lu Peng, Peng Jin, Yangbin Lin, Yu Zhou, Lichao Yang, Jie Ren, Qiang Xie*, Xin Jin*. N-oleoylethanolamide suppresses intimal hyperplasia after balloon injury in rats through AMPK/PPARa pathway. Biochemical And Biophysical Research Communications, 2018, 496(2):415-421.
4. Lu Peng#, Xuefeng Huang#, Xin Jin, Zuo Jing, Lichao Yang, Yu Zhou, Jie Ren, Yun Zhao*. Wedelolactone, a plant coumarin, prevents vascular smooth muscle cell proliferation and injury-induced neointimal hyperplasia through Akt and AMPK signaling. Experimental Gerontology, 2017, 96: 73–81.
5. Yun Zhao#, Lu Yan#, Xiu-Mei Luo#, Lu Peng, Han Guo, Zuo Jing, Li-Chao Yang, Rong Hu, Xuan Wang, Xue-Feng Huang, Yi-Qing Wang, Xin Jin. A novel PPARα agonist propane-2-sulfonicacidoctadec-9-enyl-amide inhibits inflammation in THP-1 cells. European Journal of Pharmacology, 2016, 788: 104–112.
6. Yun Zhao#, Lu Peng#, Lichao Yang, Xudong Xu, Weijie Li, Xiumei Luo, Xin Jin*, Wedelolactone Regulates Lipid Metabolism and Improves Hepatic Steatosis Partly by AMPK Activation and Up-Regulation of Expression of PPARalpha/LPL and LDLR. PloS one, 2015, 10, e0132720.
7. Yun Zhao#, Lu Peng#, Wei Lu, Yiqing Wang, Xuefeng Huang, Chen Gong, Lin He, Junhao Hong, Songsong Wu, Xin Jin*. Effect of Eclipta Prostrata on Lipid Metabolism in Hyperlipidemic Animals. Experimental Gerontology, 2015, 62: 37-44.
8. Yun Zhao#, Ping Shu#, Youzhi Zhang#, Limin Lin, Haihong Zhou, Zhentian Xu, Daqin Suo, Anzhi Xie, Xin Jin*. Effect of Centella Asiatica on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models. Oxidative Medicine and Cellular Longevity, 2014, 154295.
9. Huang Xuefeng#, Zhao Yun*, Jin Xin. Structural Characterisation of a Polysaccharide from Radix Ranunculus Ternati.Iranian journal of pharmaceutical research, 2014, 13: 1401-1405.
10. Yun Zhao#, Jinlan Ruan*, Jinhui Wang, Yue Cong, Shuang Song, Yaling Cai, Wei Fang, Daonian Zhou. Chemical constituents of radix Ranunculus ternate. Natural Product Research, 2008, 22(3): 233-240.
11. 沈燕慧#,金鑫*,赵云*,古丽米然·阿里同别克,林丽敏,舒萍,魏晓。N-(2-羟基乙基)芥酰胺对高脂血症金黄地鼠的降脂及保肝作用。药学学报,2012,47: 1252-1256
12. 陈博#,沈燕慧,卢伟,朱浩,孙丽娟,唐杨顺,赵云*,田风,金鑫。油酰乙醇胺对高脂血症大鼠降血脂及肝脏的保护作用。中国生化药物杂志,2011,374-377
13. 赵云#,阮金兰, 王金辉*,丛悦,宋爽。猫爪草化学成分研究。中药材,2010,(05):722-723
专利:
1. 金鑫,赵云,彭璐,景佐。蟛蜞菊内酯的制药用途,专利号:ZL 2015 1 0808916.4。
2. 赵云,金鑫,杨霞珍,米雨辰。蟛蜞菊内酯作为减肥药物的用途,申请号:201910710411.2
主持过的重要课题:
1. 福建省基金,2016J05204,蟛蜞菊内酯的抗动脉粥样硬化作用及其分子机制研究, 2016/04-2019/04,3.99万元,已结题,主持。
2. 国家自然科学基金青年项目,81803532,抑制NNMT对脂肪棕化的影响以及通过此途径改善动脉粥样硬化的研究,2019/01-2021/12,21万元,在研,主持。